Confirmation
1
Document Type
Poster
Location
ONU McIntosh Center; Activities Room
Start Date
24-4-2026 10:00 AM
End Date
24-4-2026 10:50 AM
Abstract
Chloride intracellular channels (CLICs) are members of a unique class of chloride channels localized in the intracellular organelles. There have been six mammalian homologues of CLIC (CLIC1-6) discovered, with two of them (CLIC4 and 5) being localized in the mitochondria. Drosophila melanogaster have one homologue, DmCLIC, which is also localized to the mitochondria. In order to understand the metabolic functions of , we investigated the role of CLIC in regulating cardiac function. To study the physiological role of CLIC, we measured the levels of sugars and lipids in the CLIC109 null mutants. We observed an increase in the level of sugars as well as triglycerides in the adult CLIC109 mutants. We further investigated the signaling pathways responsible for these observations and our initial results suggest that the TOR pathway (Target of Rapamycin) is differentially regulated in CLIC109 mutants. Given the role of TOR pathway as a central nutrient sensing and growth-regulating system in cells, we are focusing on the link between CLIC and this pathway in the context of nutritional regulation.
Recommended Citation
Oyetunji, Ibukunoluwa Einstein; Seeley, Sarah; and Gururaja Rao, Shubha, "Role of chloride intracellular channels in regulating nutrition in Drosophila" (2026). ONU Student Research Colloquium. 85.
https://digitalcommons.onu.edu/student_research_colloquium/2026/Posters/85
Restricted
Available to ONU community via local IP address and ONU login.
Role of chloride intracellular channels in regulating nutrition in Drosophila
ONU McIntosh Center; Activities Room
Chloride intracellular channels (CLICs) are members of a unique class of chloride channels localized in the intracellular organelles. There have been six mammalian homologues of CLIC (CLIC1-6) discovered, with two of them (CLIC4 and 5) being localized in the mitochondria. Drosophila melanogaster have one homologue, DmCLIC, which is also localized to the mitochondria. In order to understand the metabolic functions of , we investigated the role of CLIC in regulating cardiac function. To study the physiological role of CLIC, we measured the levels of sugars and lipids in the CLIC109 null mutants. We observed an increase in the level of sugars as well as triglycerides in the adult CLIC109 mutants. We further investigated the signaling pathways responsible for these observations and our initial results suggest that the TOR pathway (Target of Rapamycin) is differentially regulated in CLIC109 mutants. Given the role of TOR pathway as a central nutrient sensing and growth-regulating system in cells, we are focusing on the link between CLIC and this pathway in the context of nutritional regulation.