Advisor(s)
Dr. Manoranjan S D'Souza
Confirmation
1
Document Type
Poster
Location
ONU McIntosh Center; Activities Room
Start Date
24-4-2026 10:00 AM
End Date
24-4-2026 10:50 AM
Abstract
Pain is responsible for significant morbidity and mortality in the United States and all over the world. CB1 cannabinoid receptors have been reported to play a role in pain. Also, more recently sex-dependent behavioral differences after CB1 receptor activation have been reported. However, the sex-dependent effects of CB1 receptor activation on thermal pain have not been systematically assessed. This project will address this gap in knowledge. The study will use adult male and female C57BL6 mice. CB1 receptors will be activated using the synthetic cannabinoid WIN 55212. Thermal pain will be assessed using the hot plate method. Data for the project is currently being collected and analyzed. We anticipate the project will help us understand if sex (male vs. female) influences the effects of CB1 receptor activation on thermal pain.
Recommended Citation
Acheampong, Jessica; Seeley, Sarah; and DSouza, Manoranjan S., "Role of CB1 receptors in mediating thermal pain in male and female mice" (2026). ONU Student Research Colloquium. 8.
https://digitalcommons.onu.edu/student_research_colloquium/2026/Posters/8
Role of CB1 receptors in mediating thermal pain in male and female mice
ONU McIntosh Center; Activities Room
Pain is responsible for significant morbidity and mortality in the United States and all over the world. CB1 cannabinoid receptors have been reported to play a role in pain. Also, more recently sex-dependent behavioral differences after CB1 receptor activation have been reported. However, the sex-dependent effects of CB1 receptor activation on thermal pain have not been systematically assessed. This project will address this gap in knowledge. The study will use adult male and female C57BL6 mice. CB1 receptors will be activated using the synthetic cannabinoid WIN 55212. Thermal pain will be assessed using the hot plate method. Data for the project is currently being collected and analyzed. We anticipate the project will help us understand if sex (male vs. female) influences the effects of CB1 receptor activation on thermal pain.