Advisor(s)
Manoranjan D'Souza
Confirmation
1
Document Type
Poster
Location
ONU McIntosh Center; Activities Room
Start Date
24-4-2026 10:00 AM
End Date
24-4-2026 10:50 AM
Abstract
The goal of this study was to assess the behavioral effects of cocaine following activation of CB1 cannabinoid receptors in male and female mice. This study was undertaken because recently published data suggest sex-dependent behavioral differences after CB1 receptor activation. However, the sex-dependent effects of CB1 receptor activation on the rewarding and psychomotor effects of cocaine have not been systematically evaluated. This study aimed to address this gap in knowledge. The study will use adult male and female C57BL6 mice. CB1 receptors will be activated using synthetic cannabinoid WIN 55212. Behavioral effects assessed after CB1 receptor activation will include both the rewarding effects of cocaine and cocaine-induced locomotor activity. The rewarding effects of cocaine will be assessed using the conditioned place preference (CPP) test. Data for the project is currently being collected and analyzed. It is anticipated that the data will help us uncover any sex-dependent differential behavioral effects of cocaine after CB1 receptor activation.
Recommended Citation
Baughman, Cade; Lee, Jejun; Acheampong, Jessica; Choi, Jihoon; Seeley, Sarah; and DSouza, Manoranjan, "Behavioral effects of cocaine after activation of CB1 cannabinoid receptors in male and female mice" (2026). ONU Student Research Colloquium. 7.
https://digitalcommons.onu.edu/student_research_colloquium/2026/Posters/7
Behavioral effects of cocaine after activation of CB1 cannabinoid receptors in male and female mice
ONU McIntosh Center; Activities Room
The goal of this study was to assess the behavioral effects of cocaine following activation of CB1 cannabinoid receptors in male and female mice. This study was undertaken because recently published data suggest sex-dependent behavioral differences after CB1 receptor activation. However, the sex-dependent effects of CB1 receptor activation on the rewarding and psychomotor effects of cocaine have not been systematically evaluated. This study aimed to address this gap in knowledge. The study will use adult male and female C57BL6 mice. CB1 receptors will be activated using synthetic cannabinoid WIN 55212. Behavioral effects assessed after CB1 receptor activation will include both the rewarding effects of cocaine and cocaine-induced locomotor activity. The rewarding effects of cocaine will be assessed using the conditioned place preference (CPP) test. Data for the project is currently being collected and analyzed. It is anticipated that the data will help us uncover any sex-dependent differential behavioral effects of cocaine after CB1 receptor activation.