Advisor(s)

Amy Stockert, PhD
Ohio Northern University
Pharmaceutical & Biomedical Sciences
a-stockert@onu.edu

Amy Aulthouse, PhD
Ohio Northern University
Biological Sciences, Science, Technology, and Mathematics
a-aulthouse@onu.edu

Document Type

Video

Start Date

23-4-2021 9:00 AM

Description

The burden of diabetes in healthcare has grown to affect 10.5% or roughly 34.2 million people in the United States population. Over the years, cinnamon has proven to have the ability to decrease blood glucose values in Type 2 diabetes patients. This study focuses on the morphology changes in 3T3-L1 adipocyte cells after being treated by cinnamon extract that mimics cell differentiation observed in some 3-dimensional models. When inducing the differentiated cells with cinnamon it is found to modulate expression in FOXO1 in the 3T3-L1 cells, thus leading to inhibitory effects on the adipocytes. Expression of FOXO1 correlates with fat mobilization and breakdown in the cells. Data that was collected looked at placing cinnamon induced 3T3-L1 adipocyte cells into chemically differentiated environments and collecting data from time points at 48, 72 and 96 hours. This study highlights promising morphological changes in fat cells as well as preliminary FOXO1 expression results.

Restricted

Available to ONU community via local IP address and ONU login.

Share

COinS
 
Apr 23rd, 9:00 AM

3T3-L1 cells Chemically Differentiated with Cinnamon Shows Changes in FOXO1 Expression and Cell Morphology

The burden of diabetes in healthcare has grown to affect 10.5% or roughly 34.2 million people in the United States population. Over the years, cinnamon has proven to have the ability to decrease blood glucose values in Type 2 diabetes patients. This study focuses on the morphology changes in 3T3-L1 adipocyte cells after being treated by cinnamon extract that mimics cell differentiation observed in some 3-dimensional models. When inducing the differentiated cells with cinnamon it is found to modulate expression in FOXO1 in the 3T3-L1 cells, thus leading to inhibitory effects on the adipocytes. Expression of FOXO1 correlates with fat mobilization and breakdown in the cells. Data that was collected looked at placing cinnamon induced 3T3-L1 adipocyte cells into chemically differentiated environments and collecting data from time points at 48, 72 and 96 hours. This study highlights promising morphological changes in fat cells as well as preliminary FOXO1 expression results.