Title

Activities of Ceftobiprole, Linezolid, Vancomycin, and Daptomycin against Community-Associated and Hospital-Associated Methicillin-Resistant Staphylococcus aureus

Document Type

Article

Publication Date

5-26-2008

DOI

10.1128/AAC.00257-08

Abstract

We evaluated the activity of ceftobiprole against 100 community-associated methicillin-resistant Staphylo-coccus aureus (CA-MRSA) and 100 hospital-associated MRSA (HA-MRSA) isolates. Eight isolates were evaluated by time-kill studies for kill rate and potential for synergy with tobramycin. Ceftobiprole MIC50 and MIC90 values were 1 and 2 μg/ml, respectively, against CA-MRSA and HA-MRSA. In time-kill analysis, ceftobiprole was bactericidal at all concentrations tested.

Comments

This article was created while Prof. Steven Leonard was part of Wayne State University's School of Medicine.

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