Activities of Ceftobiprole, Linezolid, Vancomycin, and Daptomycin against Community-Associated and Hospital-Associated Methicillin-Resistant Staphylococcus aureus

Steven N. Leonard, Ohio Northern University
Chrissy M. Cheung, Wayne State University
Michael J. Rybak, Wayne State University

This article was created while Prof. Steven Leonard was part of Wayne State University's School of Medicine.

Abstract

We evaluated the activity of ceftobiprole against 100 community-associated methicillin-resistant Staphylo-coccus aureus (CA-MRSA) and 100 hospital-associated MRSA (HA-MRSA) isolates. Eight isolates were evaluated by time-kill studies for kill rate and potential for synergy with tobramycin. Ceftobiprole MIC₅₀ and MIC₉₀ values were 1 and 2 μg/ml, respectively, against CA-MRSA and HA-MRSA. In time-kill analysis, ceftobiprole was bactericidal at all concentrations tested.