Depression and anxiety disorders are two of the most common mental illnesses experienced by people within the United States, affecting 6.7 percent of the adult population per year. This article will focus on one specific type of depression, major depressive disorder (MDD), characterized by two or more weeks of depressed mood and/or decreased interest in normally enjoyed activities. Depression complicates treatment of other disease state(s), making successful treatment of depression essential in the management of a patient's overall health. This review will evaluate the pathophysiology, antidepressant treatment, and new approaches to treatment, specifically vortioxetine, for MDD.
Dye B, Henthorne S, Kulp M, Maiers T, Crawford Z, Petersen E. Antidepressant Therapy: A Review of Current Treatment Options and A Glance at the Future. PAW Review. 2013 May 01; 4(2):Article 10 46-51 . Available from: https://digitalcommons.onu.edu/paw_review/vol4/iss2/10. Free full text article.